Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density

HRT vs COCP for the management of premature ovarian failure

Premature ovarian failure (POF) is a loss of ovarian function under the age of 45. Spontaneous POF affects around 1% of women under the age of 40 and 5% under 45.

Women with POF have lower bone density than controls, increased risk of osteoporosis and fractures in later life compared with controls.

Combined hormone replacement therapy (HRT) or the combined oral contraceptive pill (COCP) are commonly prescribed to women with POF.

HRT is more “physiological,” because most preparations contain estradiol, which is found naturally, whereas COCPs contain the synthetic ethinyl oestradiol and higher doses of progestin.

COCPs are recognized to increase the risk of venous thrombo-embolism and are also considered a risk factor for cardiovascular and cerebrovascular disease.

In this symposium Prof Bassel Wattar and Prof Vikram Talaulikar discuss the findings of a trial by Cartwright et al which evaluated safety and efficacy of the combined oral contraceptive versus HRT on optimising bone health in women with POF.

Link to the YouTube video:

Link to the full article:


More Sessions

Welcome to the Menopause Symposium

Welcome to the Menopause Symposium, where we foster debate, share high quality health research, and inform women and health professionals on new insight in the world of menopause.


The information provided on the Menopause Symposium website is for general informational purposes only. It is not a substitute for professional medical advice. We do not endorse specific treatments, and content may change without notice. By using the site, you agree to these terms.